Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure–activity relationships
Identifieur interne : 001086 ( Main/Exploration ); précédent : 001085; suivant : 001087Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure–activity relationships
Auteurs : Wolfgang Uter [Allemagne] ; Jeanne D. Johansen [Danemark] ; Anna Börje [Suède] ; Ann-Therese Karlberg [Suède] ; Carola Lidén [Suède] ; Suresh Rastogi [Danemark] ; David Roberts [Royaume-Uni] ; Ian R. White [Royaume-Uni]Source :
- Contact Dermatitis [ 0105-1873 ] ; 2013-10.
Abstract
Contact allergy to fragrances is still relatively common, affecting ∼ 16% of patients patch tested for suspected allergic contact dermatitis, considering all current screening allergens. The objective of the review is to systematically retrieve, evaluate and classify evidence on contact allergy to fragrances, in order to arrive at recommendations for targeting of primary and secondary prevention. Besides published evidence on contact allergy in humans, animal data (local lymph node assay), annual use volumes and structure–activity relationships (SARs) were considered for an algorithmic categorization of substances as contact allergens. A total of 54 individual chemicals and 28 natural extracts (essential oils) can be categorized as established contact allergens in humans, including all 26 substances previously identified as contact allergens (SCCNFP/0017/98). Twelve of the 54 individual chemicals are considered to be of special concern, owing to the high absolute number of reported cases of contact allergy (> 100). Additionally, 18 single substances and one natural mixture are categorized as established contact allergens in animals. SARs, combined with limited human evidence, contributed to the categorization of a further 26 substances as likely contact allergens. In conclusion, the presence of 127 single fragrance substances and natural mixtures should, owing to their skin sensitizing properties, be disclosed, for example on the label. As an additional preventive measure, the maximum use concentration of 11 substances of special concern should be limited to 100 ppm. The substance hydroxyisohexyl 3‐cyclohexene carboxaldehyde and the two ingredients chloroatranol and atranol in the natural extracts Evernia prunastri and Evernia furfuracea should not be present in cosmetic products.
Url:
DOI: 10.1111/cod.12117
Affiliations:
- Allemagne, Danemark, Royaume-Uni, Suède
- Bavière, District de Moyenne-Franconie, Hovedstaden, Svealand
- Copenhague, Erlangen, Stockholm
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White</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH</wicri:regionArea><wicri:noRegion>London SE1 7EH</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Contact Dermatitis</title><title level="j" type="abbrev">Contact Dermatitis</title><idno type="ISSN">0105-1873</idno><idno type="eISSN">1600-0536</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2013-10">2013-10</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="196">196</biblScope><biblScope unit="page" to="230">230</biblScope></imprint><idno type="ISSN">0105-1873</idno></series><idno type="istex">4C18444C5C75EBC4526435B6E8A320447C1195F3</idno><idno type="DOI">10.1111/cod.12117</idno><idno type="ArticleID">COD12117</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-1873</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Contact allergy to fragrances is still relatively common, affecting ∼ 16% of patients patch tested for suspected allergic contact dermatitis, considering all current screening allergens. The objective of the review is to systematically retrieve, evaluate and classify evidence on contact allergy to fragrances, in order to arrive at recommendations for targeting of primary and secondary prevention. Besides published evidence on contact allergy in humans, animal data (local lymph node assay), annual use volumes and structure–activity relationships (SARs) were considered for an algorithmic categorization of substances as contact allergens. A total of 54 individual chemicals and 28 natural extracts (essential oils) can be categorized as established contact allergens in humans, including all 26 substances previously identified as contact allergens (SCCNFP/0017/98). Twelve of the 54 individual chemicals are considered to be of special concern, owing to the high absolute number of reported cases of contact allergy (> 100). Additionally, 18 single substances and one natural mixture are categorized as established contact allergens in animals. SARs, combined with limited human evidence, contributed to the categorization of a further 26 substances as likely contact allergens. In conclusion, the presence of 127 single fragrance substances and natural mixtures should, owing to their skin sensitizing properties, be disclosed, for example on the label. As an additional preventive measure, the maximum use concentration of 11 substances of special concern should be limited to 100 ppm. The substance hydroxyisohexyl 3‐cyclohexene carboxaldehyde and the two ingredients chloroatranol and atranol in the natural extracts Evernia prunastri and Evernia furfuracea should not be present in cosmetic products.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Bavière</li><li>District de Moyenne-Franconie</li><li>Hovedstaden</li><li>Svealand</li></region><settlement><li>Copenhague</li><li>Erlangen</li><li>Stockholm</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Uter, Wolfgang" sort="Uter, Wolfgang" uniqKey="Uter W" first="Wolfgang" last="Uter">Wolfgang Uter</name></region></country><country name="Danemark"><noRegion><name sortKey="Johansen, Jeanne D" sort="Johansen, Jeanne D" uniqKey="Johansen J" first="Jeanne D." last="Johansen">Jeanne D. Johansen</name></noRegion><name sortKey="Rastogi, Suresh" sort="Rastogi, Suresh" uniqKey="Rastogi S" first="Suresh" last="Rastogi">Suresh Rastogi</name></country><country name="Suède"><noRegion><name sortKey="Borje, Anna" sort="Borje, Anna" uniqKey="Borje A" first="Anna" last="Börje">Anna Börje</name></noRegion><name sortKey="Karlberg, Ann Herese" sort="Karlberg, Ann Herese" uniqKey="Karlberg A" first="Ann-Therese" last="Karlberg">Ann-Therese Karlberg</name><name sortKey="Liden, Carola" sort="Liden, Carola" uniqKey="Liden C" first="Carola" last="Lidén">Carola Lidén</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Roberts, David" sort="Roberts, David" uniqKey="Roberts D" first="David" last="Roberts">David Roberts</name></noRegion><name sortKey="White, Ian R" sort="White, Ian R" uniqKey="White I" first="Ian R." last="White">Ian R. White</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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